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Table 2 Efficacy outcome measures

From: Duloxetine for the long-term treatment of Major Depressive Disorder in patients aged 65 and older: an open-label study

Outcome measure Mean baseline score Mean change (SE)
   Week 6 Week 28 Week 52
CGI-Severity 4.51 -2.08 (0.11)** -2.93 (0.12)** -3.15 (0.12)**
PGI-Improvement N/A 2.33 (0.14)** 1.83 (0.16)** 1.84 (0.16)**
HAMD 17 Total Score 21.8 -13.0 (0.7)** -17.4 (0.8)** -17.5 (0.8)**
   Anxiety subscale 6.70 -3.46 (0.30)** -4.89 (0.33)** -4.90 (0.34)**
   Core subscale 8.83 -5.65 (0.33)** -7.50 (0.36)** -7.61 (0.38)**
   Maier subscale 10.7 -6.64 (0.38)** -8.90 (0.42)** -9.06 (0.44)**
   Retardation subscale 7.84 -4.49 (0.27)** -6.58 (0.30)** -6.49 (0.31)**
   Sleep subscale 3.68 -2.34 (0.21)** -2.84 (0.23)** -2.83 (0.24)**
   HAMD17 Item 1 2.64 -1.73 (0.11)** -2.30 (0.13)** -2.30 (0.13)**
   HAMD17 Item 3 0.74 -0.58 (0.06)** -0.59 (0.06)** -0.61 (0.06)**
BDI-II Total Score 29.5 -15.8 (1.0)** -22.3 (1.1)** -22.0 (1.1)**
Sheehan Disability Scale     
   Work item 6.91 -3.01 (0.32)** -4.60 (0.37)** -4.27 (0.39)**
   Family item 6.82 -3.63 (0.32)** -4.88 (0.35)** -4.95 (0.37)**
   Social item 7.27 -3.45 (0.34)** -4.57 (0.38)** -4.85 (0.40)**
  1. ** p < .001 from t-test for mean change
  2. CGI-Severity = Clinical Global Impression of Severity; PGI-Improvement = Patient Global Impression of Improvement; HAMD17 = 17-item Hamilton Rating Scale for Depression; BDI-II = Beck Depression Inventory-II
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BMC Geriatrics

ISSN: 1471-2318

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